منابع مشابه
Hormonal Influences on Urethan Carcinogenesis in C3h/f Mice.
for lung tissue (29). Subsequently, it has been shown to produce tumors in a variety of tissues of the mouse (37). Hemorrhagic lesions (6, 34, 37) and hemangiomas (20, 22, 32) in the livers of mice have been observed following the administration of unethan. Heston et al. (18) provided data obtaine4 from unethan-tneated C3H mice that permitted the addition of hepatomas to the list of neoplasms i...
متن کاملBRCA1 in hormonal carcinogenesis: basic and clinical research.
The breast and ovarian cancer susceptibility gene-1 (BRCA1) located on chromosome 17q21 encodes a tumor suppressor gene that functions, in part, as a caretaker gene in preserving chromosomal stability. The observation that most BRCA1 mutant breast cancers are hormone receptor negative has led some to question whether hormonal factors contribute to the etiology of BRCA1-mutant breast cancers. Ne...
متن کاملA human prostatic epithelial model of hormonal carcinogenesis.
The effects of stromal and hormonal environment on the immortalized but nontumorigenic human prostatic epithelial cell line BPH-1 were investigated in an in vivo model. BPH-1 cells were recombined with rat urogenital sinus mesenchyme (UGM), and the tissue recombinants were grafted to the renal capsule of adult male athymic mouse hosts. BPH-1 + UGM recombinants formed solid branching epithelial ...
متن کاملThe Role of Hormonal and Dietary Factors in Pancreatic Carcinogenesis
The pancreatic cancer continues to represent an important problem, as a cancer with extremely poor prognosis. To date more than 16 chemicals have been shown to induce pancreatic tumors, in animal models. The tumors developed in rats are essentially of acinar type and those in hamsters mostly of ductal type. Many studies proved the direct or indirect role of hormonal and dietary factors in pancr...
متن کاملRole of hormonal environment, partial hepatectomy, and dose of ethylnitrosourea in renal carcinogenesis.
For evaluation of factors modifying renal carcinogenesis, several groups of 6-week-old C57BL X C3H Fj mice of both sexes were exposed once to 60 or 121)ng ot ethylnitrosourea per g of body weight. This treatment was preceded in some groups by partial hepatectomy and/or ovariectomy. Animals were killed at 90 weeks of age, and the incidence of renal tumors was evaluated. Ethylnitrosourea induced ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2000
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/21.3.427